Early identification of coronary artery disease (CAD) is difficult using traditional risk factors and risk scores. While it is well known that CAD has substantial heritability and a polygenic architecture, genomic risk scores to help predict early CAD have yet to be shown especially effective. In this study, Inouye et al constructed a genomic risk score based on 1.7 million single nucleotide polymorphisms (SNPs) to predict lifetime risk trajectories for CAD. The researchers developed built a new genomic risk score for CAD (called metaGRS) using a meta-analytic approach to combine large-scale, genome-wide, and targeted genetic association data. The score was based on 3 other genetic risk scores and included 1.7 million genetic variants. MORE
Esteemed Elsevier author, Meir Kryger, MD, FRCP, is a Professor of Pulmonary Medicine and Clinical Professor of Nursing at the Yale School of Medicine. Dr. Kryger is a trailblazer in the field of sleep medicine. MORE
Early identification of coronary artery disease (CAD) is difficult using traditional risk factors and risk scores. While it is well known that CAD has substantial heritability and a polygenic architecture, genomic risk scores to help predict early CAD have yet to be shown especially effective. In this study, Inouye et al constructed a genomic risk score based on 1.7 million single nucleotide polymorphisms (SNPs) to predict lifetime risk trajectories for CAD. The researchers developed built a new genomic risk score for CAD (called metaGRS) using a meta-analytic approach to combine large-scale, genome-wide, and targeted genetic association data. The score was based on 3 other genetic risk scores and included 1.7 million genetic variants. MORE
This second edition of book on transplant pathology in the Diagnostic Pathology series addresses the pathological processes associated with renal, liver, heart, lung, intestinal, and pancreas transplants. The first edition was published in 2013. MORE
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