Debra L. Beck and Eugene Braunwald, MD  After percutaneous coronary intervention (PCI), guidelines recommend indefinite maintenance therapy with a single antiplatelet agent after the initial 6- to 12-months of dual antiplatelet therapy (DAPT). Aspirin is the most widely used standard antiplatelet agent, with clopidogrel recommended as an alternative strategy. The HOST-EXAM trial was an investigator-initiated, prospective, randomized, open-label, multicenter trial comparing the efficacy and safetyMORE