Hematopathology, 3rd Edition

By: Jaffe, Elaine S., MD; Arber, Daniel A., MD; Campo, Elias, MD, PhD; Orazi, Attilio, FRCPath; Quintanilla-Martinez, Leticia, MD; Rimsza, Lisa M., MD

ISBN: 9780323831659

Publication Date: September 3, 2024

Reviewer: Anamarija Perry, MD (University of Michigan Medical School)

Description

This book covers reactive and neoplastic disorders of lymphoid organs and tissues and bone marrow. The previous edition was published in 2017. This edition adopts the 2022 International Consensus Classification (ICC).

Purpose

The aim of this updated edition is to provide a concise, up-to-date, and practical review of hematopathology. The book achieves its stated goals.

Audience

This book will be useful to anyone who interprets lymphoid tissue and bone marrow biopsies, including hematopathologists, surgical pathologists, pathology residents, and hematopathology fellows. Clinical hematologists and fellows will also find it useful.

Features

The book contains five parts divided into 59 chapters. The first part covers technical aspects of hematopathology, such as the processing of the lymph node biopsy specimen and different ancillary methods (e.g., immunohistochemistry, flow cytometry, molecular studies). Part II covers normal histology of hematopoietic tissues as well as reactive conditions. The largest third part focuses on lymphoid neoplasms including mature B-, T- and NK-cell neoplasm and precursor B- and T-cell neoplasms. Part IV covers myeloid, histiocytic, and related proliferations, while Part V covers immunodeficiency disorders. The book concludes with a comprehensive index. The book covers each entity in a systematic fashion that includes descriptions of morphologic, immunophenotypic, and clinical features, along with relevant genetic findings. It is richly illustrated with numerous microscopic images of great quality. Numerous useful tables complement the text, which describe salient features of some entities or compare different diagnoses. Each chapter concludes with a box of pearls and pitfalls and a list of selected key references. A complete list of references is available online.

Assessment

This book remains one of the must-haves for anyone signing out hematopathology specimens. It is comprehensive and appropriate for all levels of expertise, and it is a great learning resource for hematopathology fellows. The section on differential diagnosis is particularly useful for everyday sign-out. Although the book uses 2022 ICC, it incorporates the terminology used by the fifth edition of World Health Organization (WHO) Classification, and, when appropriate, discusses the rationale for the preferred ICC terminology adopted by this book. Moreover, Chapter 12 features a table that provides detailed comparison of current classification systems for lymphoid neoplasm. The microscopic images are appropriate and include not only usual, but also rare morphologic variants for many entities. This book will benefit all hematopathologists, as well as surgical pathologists who sign out hematopathology specimens.

©Doody’s Review Service, 2025, Anamarija Perry, MD (University of Michigan Medical School), Doody’s Score: 99 – 5 Stars!

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