Zipes and Jalife’s Cardiac Electrophysiology: From Cell to Bedside, 8th Edition

By: Jose Jalife, MD, PhD and William Gregory Stevenson, MD

ISBN: 9780323757454

Pub Date: December 17, 2021

Reviewed By:  Matthew Alan Colna, MD (East Tennessee State University Quillen College of Medicine) 

Description  

This is a comprehensive textbook to present the current state of cardiac electrophysiology and arrhythmias. The eighth edition has significant enhancements with removal of 30 chapters from the previous edition and replacement of those chapters that reflect the advances in the field. The rest of the book has been extensively reviewed and updated to reflect the most current state of electrophysiology. 

Purpose  

The purpose of the book is to provide a comprehensive manual to the area of electrophysiology and arrhythmias. The book aims to address a multitude of aspects specific to electrophysiology to bridge the cellular basis of disease process to the application of bedside treatment of the patient. The book adequately covers the proposed objectives to solidify the complex concepts with the use of detailed texts and visual aids. The use of detailed graphics, charts, and graphs provides excellent visual aids to guide physicians’ understanding. 

Audience  

This book specifically addresses the clinical complexities of electrophysiology and, thus, the intended audience of this book includes cardiologists and cardiology fellows with a specific interest in electrophysiology as well as electrophysiologists and electrophysiology fellows. The level of the writing is appropriate for the intended audience. The authors and contributors are respected cardiologists and professors of cardiology. 

Features  

The book is separated into two major parts. The first part is broken down into 10 sections and 59 chapters focused on the foundations of basic and translational cardiac electrophysiology. The 10 sections in order are Structural and Molecular Bases of Ion Channel Function (eight chapters), Biophysics of Cardiac Ion Channel Function (eight chapters), Intermolecular Interactions and Cardiomyocyte Electrical Function (eight chapters), Cell Biology of Cardiac Impulse Initiation and Propagation (five chapters), Five Models of Cardiac Excitation (eight chapters), Neural Control of Cardiac Electrical Activity (five chapters), Arrhythmia Mechanism (five chapters), Molecular Genetics and Pharmacogenomics (four chapters), Pharmacologic, Genetic and Cell Therapy of Ion Channel Dysfunction (four chapters), and a new section on Cell Biology and Electrophysiology of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (four chapters). The second part contains 78 chapters divided into 10 sections devoted to clinical cardiac electrophysiology, including sections on Diagnostic Evaluation (10 chapters), Supraventricular Tachyarrhythmias (nine chapters), Ventricular Tachyarrhythmias (24 chapters), Syncope (four chapters), Arrhythmias in Special Populations (seven chapters), Congenital Heart Disease and Pediatrics (three chapters), Pharmacologic Therapy (three chapters), Devices of Arrhythmia Management (seven chapters), Catheter and Surgical Mapping and Ablation (11 chapters), and Drug Discovery for Cardiac Arrhythmias (one chapter). The manner in which the book covers the extremely complex entity of cellular mechanisms of arrhythmias and genetics is done in a way that is easy to understand. The book builds on itself, utilizing concepts taught earlier in the text to explain treatment mechanisms. The application of detailed graphics, charts, and tables complements the text and enhances the learning and ease of understanding. 

Assessment   

The quality of the content of this book is excellent. Given the complexity of the subject manner, this book is a valuable resource for cardiologists and cardiology fellows with a specific interest in electrophysiology, as well as for electrophysiologists and electrophysiology fellows to further their knowledge and understanding of the complex topic of electrophysiology. The book is organized in a way that allows readers to develop an advancing framework that enables them to build upon and better grasp more advanced topics. The eighth edition provides updated knowledge and treatment strategies based on up-to-date research that was not in the previous edition. 

©Doody’s Review Service, 2022, Matthew Alan Colna, MD (East Tennessee State University Quillen College of Medicine)

Doody’s Score: 99 – 5 Stars! 

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