Debra L. Beck and Eugene Braunwald, MD Pulmonary arterial hypertension (PAH) is a rare and progressive disorder characterized by pulmonary vascular remodeling resulting in high pulmonary artery pressure, cellular proliferation, and poor long-term outcomes. Mutations that lead to dysfunctional bone morphogenetic protein pathway signaling has been linked to both the hereditary and idiopathic subtypes. Sotatercept is a novel, first-in-class fusion protein, binds activins and growth differentiation factors in an attempt
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