Oral anticoagulation (OAC) is superior to dual antiplatelet therapy (DAT) in preventing stroke in patients with atrial fibrillation (AF), but DAT is superior to OAC in preventing stent thrombosis and ischemic events after percutaneous coronary intervention (PCI). MORE

Difficulties with harvest of the Semitendinosus (ST) and, if necessary, Gracilis are vexing for many Orthopaedic Surgeons. It is the primary force that drives many surgeons to use allografts despite the fact the results of allografts are clearly substantially inferior to autografts. I used hamstrings from the beginning of my career in 1985 for open ACL reconstruction. I used large incisions and harvest was easy. MORE

There are conflicting data on the comparative safety and effectiveness of bivalirudin compared with unfractionated heparin (UFH) in relation to the planned use of glycoprotein IIb/IIIa inhibitors (GPIs). The issue has been made more unclear with the expansion of antithrombotic therapies available for patients with acute coronary syndromes (ACS) undergoing percutaneous coronary intervention (PCI), which has led to a reduction in planned GPI use. This analysis of the MATRIX trial assessed the efficacy and safety of bivalirudin compared with UFH with or without GPIs in patients with ACS who underwent invasive management. In the MATRIX (Minimizing Adverse Haemorrhagic Events by Transradial Access Site and Systemic Implementation of AngioX) trial, 7,213 patients with ACS were randomly assigned to receive either bivalirudin (with GPIs restricted to bailout use) or UFH (with GPIs use left to the discretion of the operator). MORE

The esteemed Diagnostic Pathology series is comprised of visually stunning and easy-to-use references covering all aspects of pathology. The Diagnostic Pathology series is packed with high-quality, carefully annotated color images depicting classic pathological features as well as variant patterns that are prone to creating diagnostic problems. MORE